Each capsule of Mg-Orotate 500™ supplies 500 mg of magnesium as Magnesium Orotate. Orotic acid and its salts have been demonstrated to significantly improve cardiac function in settings associated with ischemia–reperfusion (I/R) injury. Additionally, when administered at the onset of reperfusion following ischemia in animals, it was noted to significantly preserve left ventricle (LV) function, and also reduced infarct size.